Transplant rejection and paradigms lost

Renal Transplant Rejection

Introduction: Determining if the cause of renal allograft dysfunction in the early post transplant period is due to rejection or other reasons is a daunting task for the clinician. Clinical signs and symptoms alone are not helpful in clearly distinguishing the numerous causes of renal dysfunction. Various noninvasive tests including imaging studies have also been unsuccessful in distinguishing ...

Antibody-Mediated Lung Transplant Rejection.

Antibody-mediated rejection after lung transplantation remains enigmatic. However, emerging evidence over the past several years suggests that humoral immunity plays an important role in allograft rejection. Indeed, the development of donor-specific antibodies after transplantation has been identified as an independent risk factor for acute cellular rejection and bronchiolitis obliterans syndro...

Transplant rejection in terrestrial molluscs

To know whether or not molluscs are capable of recognizing tissue allo-antigens, dorsal skin-allografts were exchanged between adult terrestrial slug, Incilaria fruhstorferi. We succeeded for the first time in orthotopic transplantation of allografts and observed chronic rejection of allografts. Cellular changes in the rejection process continued over for 40 days. Two functional types of “effec...

Haptoglobin enhances cardiac transplant rejection.

RATIONALE Early graft inflammation enhances both acute and chronic rejection of heart transplants, but it is unclear how this inflammation is initiated. OBJECTIVE To identify specific inflammatory modulators and determine their underlying molecular mechanisms after cardiac transplantation. METHODS AND RESULTS We used a murine heterotopic cardiac transplant model to identify inflammatory mod...

"Paradigms Lost": On Theory and Method in Research in Marketing